Taking melatonin for 30 days can increase ZnSOD (superoxide dismutase) by 31%.
"Conclusions: It was estimated that the short- and long-lasting hypokinesis leads to an increase in ROS generation, what is confirmed by the increase in CuZn-SOD activity. The results of the study on superoxide dismutase activity indicate that oral administration of melatonin for the period of 30 days has a more favorable influence on antioxidative processes than 10-day's melatonin intake."
Mrowicka, Małgorzata et al. “Wpływ melatoniny na aktywność dysmutazy ponadtlenkowej (CuZn-SOD) w krwinkach czerwonych chorych w okresie hipokinezji krótko- i długoterminowej” [Effect of melatonin on activity of superoxide dismutase (CuZn-SOD) in erythrocytes of patients during short- and long-term hypokinesis]. Wiadomosci lekarskie (Warsaw, Poland : 1960) vol. 63,1 (2010): 3-9.
